Grants Pertaining to the Hedgehog Pathway

	Hedgehog Signaling Pathway Database
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Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
shh,twhh	Danio rerio	Neuronal		Specification of the Zebrafish Ventral Neural Tube	Halpern, Marnie	NSF-IOB	0080087	abstract
en	Drosophila melanogaster	Embryo		DNA Binding-Independent Transcriptional Regulation by Runt	Gergen, John	NSF-MCB	0090956	abstract
hh	Helobdella robusta	Embryo		Cellular and Molecular Events in Early Leech Development	Weisblat, David	NSF-IOB	0091261	abstract
hh	Schistocerca americana	Eye		Functional Analysis of Eye Development in the Grasshopper	Friedrich, Markus	NSF-IOB	0091926	abstract
Shh	Danio rerio.Astyanax mexicanus	Teeth		Modularity in the Development and Evolution of the Dentition of Teleost Fishes	Stock, David	NSF-IOB	0092487	abstract
en	Annelids	Embryo		The Formation and Evolution of the Metameric Body Plan in Basal Annelids	Martindale, Mark	NSF-IOB	0094925	abstract
Shh	Astyanax mexicanus	Eye		Evolution of Eye Regression in Cavefish	Jeffery, William	NSF-IOB	0110275	abstract
en				MRI: Procurement of a Shared Confocal Microscope Facility at the Institute of Neurobiology	Miller, Mark	NSF-DBI	0115825	abstract
shh,gli	Mus musculus	Neuronal		Molecular Control of Shh/Gli Signalling in the Vertebrate CNS	Matise, Michael	NSF-IOB	0131264	abstract
en	Amphioxus	Embryo		Conservation and Non-Conservation of Engrailed Gene Regulation in Metazoan Evolution: Amphioxus as a Model for the Ancestral Vertebrate	Holland, Linda	NSF-IOB	0236171	abstract
en	Butterfly	Embryo, wing		The Role of Developmental Genes in Controlling Butterfly Eyespot Patterns	Monteiro, Antonia	NSF-IOB	0316283	abstract
hh,shh,ihh,ehh,dhh,twhh				RUI: Acquisition of Protein Purification and Analysis Instrumentation to Enhance Biochemical Research and Education at the College of the Holy Cross	Mills, Kenneth	NSF-DBI	0320824	abstract
en	Drosophila melanogaster	Embryo		Genetics of Runt-dependent Transcriptional Regulation	Gergen, John	NSF-MCB	0344486	abstract
en				Structure and Selectivity of Designed Metallohomeodomains	Franklin, Sonya	NSF-MCB	0451199	abstract
en	Butterfly	Embryo,wing		The Role of Developmental Genes in Controlling Butterfly Eyespot Patterns II	Monteiro, Antonia	NSF-IOB	0516705	abstract
iguana	Danio rerio	Embyro		Analysis of the role of the zebrafish iguana gene in hedgehog signalling	INGHAM,Philip	Wellcome Trust-UK	074974/Z/04/Z
shh	Mus musculus	ECM		Proteoglycans Modulate Sonic Hedgehog Responses	CHAN, JENNIFER	NIH-NICHD	1K08HD048595-01	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
Pka,ptch1	Mus musculus	neuronal,brain	cancer	PKA modulation of hedgehog: mouse medulloblastoma model	WASCHEK, JAMES	NIH-NCI	1R01CA110384-01A1	abstract
smo,Hes5,notch2	Mus musculus	Neuronal,brain	cancer	bHLH Factors in Medulloblastoma Genesis and Maintenance	OLSON, JAMES	NIH-NCI	1R01CA112350-01A1	abstract
shh	Mus musculus,Homo sapiens	Pancreas	cancer	Hedgehog Inhibitors in Pancreas Cancer	MAITRA, ANIRBAN	NIH-NCI	1R01CA113669-01	abstract
Gli		Mammary	cancer	Gli Control of PTH-rP and Osteolysis in Breast Cancer	MUNDY, GREGORY	NIH-NCI	1R01CA114000-01
shh		stem cells	cancer	Developmental pathways, cancer, and DNA hypermethylation	BAYLIN, STEPHEN	NIH-NCI	1R01CA116160-01	abstract
shh	Homo sapiens, Mus musculus	stem cells	cancer	Hedgehog signaling in tissue injury and carcinogenesis	BEACHY, PHILIP	NIH-NCI	1R01CA116586-01	abstract
Shh				Can abnormal Shh signaling cause ED?	PODLASEK, CAROL		1R01DK068507-01A1
Shh,ptc				Receptor Trafficking and the Response to Shh	ROELINK, HENK		1R01GM072207-01A2
shh	Mus musculus			Hedgehog signaling and intracellular transport	EGGENSCHWILER, JONATHAN	NIH-NICHD	1R01HD050761-01	abstract
shh, ihh, ptch, smo, Gli1, hip,Bmi-1	Homo sapiens	Liver	cancer	Hedgehog signaling in human hepatocellular carcinoma	CHEN, XIN	NIH-NCI	1R21CA113393-01	abstract
shh,ptc	Mus musculus	Pancreas	cancer	Hedgehog signaling in pancreatic neoplasia	MAITRA, ANIRBAN	NIH-NIDDK	1R21DK072532-01	abstract
shh	Mus musculus	Hair		Molecular Regualtion of Hair Follicle Morphogenesis	DLUGOSZ, ANDRZEJ	NIH-NIAMS	2R01AR045973-06	abstract
Ptch1,smo,Gli1,Gli2,Gli3, GH2	Mus musculus	epithelia	cancer	Molecular Basis of Epithelial Skin Cancer	DLUGOSZ, ANDRZEJ	NIH-NCI	2R01CA087837-05A1	abstract
shh	Mus musculus	Bone	Chondrodysplasia	Molecular Studies of X-Linked Chondrodysplasia Punctata	HERMAN, GAIL	NIH-NICHD	2R01HD038572-14	abstract
shh,ptc,smo,gli	Mus musculus,Rattus norvegicus	Angiogenesis,heart		Progenitor Cells in Vascular Biology	LOSORDO, DOUGLAS	NIH-NHLBI	2R01HL057516-09	abstract
shh	Mus musculus	Neuronal		Transcriptional control of sonic hedgehog signaling	EPSTEIN, DOUGLAS	NIH-NINDS	2R01NS039421-06	abstract
shh	Mus musculus	Limb		Hedgehog signaling and organogenesis of the limb	TABIN, CLIFFORD	NIH-NICHD	2R37HD032443-11	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
Shh,disp,ptch1, ptch2, gas1 and hip1	Gallus gallus,Mus musculus	Neuronal,Limb	cancer	Regulation of CNS and Limb Polarity by Sonic Hedgehog	MCMAHON, ANDREW	NIH-NINDS	2R37NS033642-11	abstract
Hh	Drosophila melanogaster	embryo,imaginal disc		Mechanisms of Hedgehog Distribution and Signaling	THE, SIU		3R01GM066220-03S1
gli2		Bone		Regulation of PTHrP expression in chondrocytes by Gli2	STERLING, JULIE		5F32AR051639-02
smo				Determinants of Smoothened Activity	WILLIAMS, ELIZABETH		5F32GM071168-02
smo				Determinants of Smoothened Activity	WILLIAMS, ELIZABETH		5F32GM071168-02
Ift 88				Analysis of Flexo/lft88, a novel regulator of Hh pathway	LIU, AIMIN		5F32HD045090-03
sister of open brain				Characterization and Cloning of Sister of Open Brain	QIN, JIAN		5F32NS050480-02
shh	Mus musculus	Neuronal		Specification of Cortical Interneurons	ANDERSON, STEWART	NIH-NIMH	5K02MH070031-02	abstract
Shh,Beg4	Mus musculus	Epithelia	cancer	Genetic Analysis of the Sonic Hedgehog Target Gene BEG4	CALLAHAN, CHRISTOPHER	NIH-NIAMS	5K08AR047803-05	abstract
Shh,ptc,gli	Mus musculus	Neuronal, brain	cancer	Hedgehog, Patched, and Gli in Medulloblastoma	WEINER, HOWARD	NIH-NCI	5K08CA093450-04	abstract
shh	Homo sapiens	Prostate, Genital		Hedgehog Pathway in Urogenital Sinus Development	BERMAN, DAVID	NIH-NIDDK	5K08DK059375-05	abstract
shh	Mus musculus,Homo sapiens	Pancreas	cancer	The Hedgehog Pathway and Pancreatic Neoplasia	THAYER, SARAH	NIH-NIDDK	5K08DK071329-02	abstract
ptch,smoh	Mus musculus,Homo sapiens	Embyro		Regulation of Hedgehog Receptor Trafficking and Function	KARPEN, HEIDI	NIH-NICHD	5K08HD042078-04	abstract
Shh			cancer	Teratogens as probes of Sonic hedgehog signaling	COOPER, MICHAEL		5K08NS002133-05
ptc	Homo sapiens	Mammary	cancer	Novel Gene Networks in Breast Development and Cancer	OSBORNE, C	NIH-NCI	5P01CA030195-23	abstract
Ptc1,Shh	Mus musculus	mammary	cancer	PTC1 Hedgehog Receptor in Mammary Development /Neoplasia	LEWIS, MICHAEL	NIH-NCI	5P01CA030195-230024	abstract
Gli				ENVIRONMENT & GLI GENES IN NORMAL DEVELOPMENT & DISEASE	IANNACCONE, PHILIP		5P01ES010549-05
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
shh	Mus musculus	Neuronal	Neurodegeneration	Genetic Analysis of Neurodegeneration	ACKERMAN, SUSAN	NIH_NIA	5R01AG019358-04	abstract
ptch		Thyroid		THYROID-SPECIFIC RET/PTC ONCOGENE	JHIANG, SISSY	NIH-NCI	5R01CA060074-10
hh,ptc,fu,cos2,ci	Drosophila melanogaster	cell line	cancer	RECONSTITUTION OF A HEDGEHOG SIGNALING COMPLEX	ROBBINS, DAVID	NIH-NCI	5R01CA082628-08	abstract
sufu	Mus musculus	epithelia	cancer	Suppressor of fused gene in Carcinogenesis	BALE, ALLEN	NIH_NCI	5R01CA093908-02	abstract
Gli			cancer	Role of GLI in Tumor progression	RUPPERT, J	NIH-NCI	5R01CA094030-04
Shh,ptch1,smo	Gallus gallus	Neuronal,muscle,stem cells		Sonic Hedgehog Target Genes in Development and Cancer	EMERSON, CHARLES	NIH-NCI	5R01CA094089-04	abstract
smo,gli1	Mus musculus	epithelia	cancer	Molecular Basis of Hedgehog Signaling in Carcinogenesis	XIE, JINGWU	NIH_NCI	5R01CA094160-04	abstract
ptc	Mus musculus	Epithelia	cancer	Basal Cell Carcinoma:Molecular Pathogenesis & Prevention	BICKERS, DAVID	NIH-NCI	5R01CA097249-04	abstract
Gli3				Mechanism of Gli3 processing in Hedgehog signaling	WANG, BAOLIN	NIH-NCI	5R01CA111673-02
dhh,ihh,shh	Mus musculus	Pancreas	cancer,diabetes	Embryonic Signaling Pathways in Pancreatic Cancer	HEBROK, MATTHIAS	NIH-NCI	5R01CA112537-02	abstract
shh,smo	Mus musculus	Ear		Regulating dorsoventral polarity within the inner ear	EPSTEIN, DOUGLAS	NIH-NIDCD	5R01DC006254-03	abstract
shh	Gallus gallus,Mus musculus	Bone,epithelia		MORPHOGENESIS OF CRANIOFACIAL PRIMORDIA	HELMS, JILL	NIH-NIDCR	5R01DE012462-07	abstract
shh	Homo sapiens, Mus musculus	Prostate	cancer	Sonic Hedgehog Induces Prostate Development	BUSHMAN, WADE	NIH-NIDDK	5R01DK052687-08	abstract
ihh,dhh,hip	Mus musculus	pancreas		Effects of Hedgehog Signaling on Pancreas Organogenesis	HEBROK, MATTHIAS	NIH-NIDDK	5R01DK060533-03	abstract
shh	Mus musculus	Epithelia,endoderm		Epithelial-mesenchymal interactions in gut morphogenesis	RUBIN, DEBORAH	NIH-NIDDK	5R01DK061216-06	abstract
ihh	Mus musculus	bone	osteoporosis	Indian Hedgehog Signaling in Osteoblast Differentiation	LONG, FANXIN	NIH-NIDDK	5R01DK065789-02	abstract
Hh,ptc,fu,ci,en	Drosophila melanogaster	Embryo		MOLECULAR MECHANISMS IN DEVELOPMENT	KORNBERG, THOMAS	NIH-NIGMS	5R01GM030637-23	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
hh,pka	Drosophila melanogaster	Embryo		Hedgehog signaling in Drosophila	KALDERON, DANIEL	NIH-NIGMS	5R01GM041815-17	abstract
hh,pka,Slimb,rasp	Drosophila melanogaster	Embryo	cancer	REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA	JIANG, JIN	NIH-NIGMS	5R01GM061269-05	abstract
Shh				Characterization of a soluble form of Sonic Hedgehog	ROBBINS, DAVID		5R01GM064011-05
hh,ext1,ext2	Drosophila melangaster	embryo,imaginal disc		Mechanisms of Hedgehog Distribution and Signaling	THE, SIU	NIH-NIGMS	5R01GM066220-03	abstract
hh,ptc,smo,fu,cos2,ci	Drosophila melanogaster	Embryo		Regulation of Hh/Ci signaling by Cos2 and its partners	JIANG, JIN		5R01GM067045-03
Smo,ci,hh	Drosophila melanogaster	embryo		Mechanism of Hedgehog signal transduction	HOOPER, JOAN	NIH-NIGMS	5R01GM069881-02	abstract
Gli2				The molecular regulation of Gli2 in Hedgehog signaling	WANG, BAOLIN		5R01GM070820-02
Gli2,gli3,shh	Mus musculus	Neuronal, Limb,epithelia		Roles of Mouse Gli Genes in Hedgehog Signaling	JOYNER, ALEXANDRA	NIH-NICHD	5R01HD035768-09	abstract
hh,shh,ptc,smo	Mus musculus	Neuronal Limb		MOLECULAR MECHANISMS OF HEDGEHOG RECEPTOR FUNCTION	BEACHY, PHILIP	NIH-NICHD	5R01HD039306-05	abstract
Shh		Neuronal		Factors Influencing Shh Signaling in the Forebrain	KOHTZ, JHUMKU		5R01HD044745-03
shh	Dano rerio	Neuronal, Muscle		Selecting for novel Hedgehog signaling mutations	DEVOTO, STEPHEN	NIH-NICHD	5R01HD044929-03	abstract
ptc,smo,hip,shh	Mus musculus	Embryo		Hedgehog signal modulation in mammalian development	CHUANG, PAO-TIEN	NIH-NHLBI	5R01HL067822-05	abstract
shh	Xenopus lavis, Gallus gallus	Angiogenesis,Heart		Embryonic Blood Vessel Formation	KRIEG, PAUL	NIH-NHLB	5R01HL074184-03	abstract
Gli				Function of the Gli Genes in Sonic Hedgehog Signaling	RUIZ I ALTABA, ARIEL		5R01NS037352-08
shh,Gli2,Gli3,Pax6	Mus musculus	Neuronal, brain		Sonic Hedgehog Signaling in the Mammalian Telencephalon	FISHELL, GORDON	NIH-NINDS	5R01NS039007-06	abstract
gli	Danio rerio	Neuronal		SIGNALING CELL SPECIFICATION FOREBRAIN	KARLSTROM, ROLF	NIH-NINDS	5R01NS039994-04	abstract
shh,rab23	Mus musculus	Neuronal		Genetic Analysis of Mouse Nervous System Development	ANDERSON, KATHRYN	NIH-NINDS	5R01NS044385-04	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
ptc,disp	Drosophila melanogaster			Niemann Pick C disease in Drosophila	BHAT, KRISHNA		5R01NS045261-03
shh,FoxM1	Mus musculus	neuronal		Mechanisms of hedge-hog induced neuroproliferation	ROWITCH, DAVID	NIH-NINDS	5R01NS047527-02	abstract
Shh	Mus musculus	pharyngeal		Role of Sonic hedgehog in pharyngeal organ development	MANLEY, NANCY	NIH-NICHD	5R03HD043479-02	abstract
shh	Danio rerio	Bone,epithelia		Craniofacial defects in ethanol-exposed zebrafish	AHLGREN, SARA	NIH-NIAAA	5R21AA013596-03	abstract
ihh	Mus musculus	Genital		Molecular Analysis of Uterine Receptivity	DEMAYO, FRANCESCO	NIH-NICHD	5U01HD042311-04	abstract
ptc	Homo sapiens	epithelia	cancer	BASAL CELL CARCINOMA CHEMOPREVENTION IN BCNS PATIENTS	EPSTEIN, ERVIN	NIH-NCI	5U19CA081888-05	abstract
dhh,ihh	Homo sapiens, Rattus norvegicus	Pancreas,stem cells	cancer,diabetes	Program Project,Restoration of Endocrine Pancreas Funct*	HABENER, JOEL	NIH-NIDDK	5U19DK061251-03	abstract
Gli				COMPARATIVE GENETICS OF GLI FUNCTION	SCHIER, ALEXANDER		7R01DE016779-02
hh,fu,cos2,ci.Sxl	Drosophila melanogaster	Embryo	cancer	Hedgehog Signaling and Sex-lethal Protein Localization	HORABIN, JAMILA	NIH-NIGMS	7R01GM061705-04	abstract
en				Molecular Analysis of Developmental Mutations	O'Farrell, Patrick	NSF-IOB	8719293	abstract
en	Drosophila melanogaster	Embryo		Nuclear Migration and Early Zygotic Gene Action in Drosophila	Karr, Timothy	NSF-IOB	8802152	abstract
en	Drosophila melanogaster	Embryo		Molecular and Genetic Characterization of the Drosophila Trans-acting Factor Elf-1	Bray, Sarah	NSF-MCB	8917480	abstract
en	Drosophila melanogaster	Embryo		Molecular Analysis of Developmental Mutations	O'Farrell, Patrick	NSF-IOB	9021142	abstract
en	Drosophila melanogaster	Embryo		Molecular Analysis of Developmental Mutations	O'Farrell, Patrick	NSF-IOB	9317299	abstract
hh	Butterfly	Embryo,wing		Pattern Formation and Eyespot Determination in Butterfly Wings	Carroll, Sean	NSF-IOB	9418449	abstract
en	Helobdella triserialis	Embryo		RPG: Molecular & Cellular Interphyletic Homology of Segmentation	Wedeen, Cathy	NSF-IOB	9509099	abstract
hh,shh,ptc,ptc		Embryo		U.S.-France Cooperative Research: Molecular Dissection of the Hedgehog/patched Signal Transduction Pathway	Scott, Matthew	NSF-OISE	9603417	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
ihh	Mus musculus	Endoderm,mesoderm		Indian Hedgehog and Early Mouse Embryogenesis	Grabel, Laura	NSF-IOB	9604367	abstract
shh	Danio rerio	Neuronal		Specification of the Zebrafish Ventral Neural Tube	Halpern, Marnie	NSF-IOB	9604844	abstract
en	Annelids	Embryo		Dissertation Research: Involvement of Embryonic Developmental Processes in Regeneration and Asexual Reproduction: a Comparative Analysis in Annelids	Wray, Gregory	NSF-DEB	9623565	abstract
en	Drosophila melanogaster	Embryo		The Identification of Orthodenticle-interacting Genes in Drosophila	Finkelstein, Robert	NSF-IOB	9630394	abstract
en	Amphioxus	Embro		Developmental Genetics of Amphioxus: Insights into the Origin and Evolution of the Vertebrate Body Plan	Holland, Nicholas	NSF-IOB	9630938	abstract
hh	Drosophila melanogaster	Embryo, eye		Pattern Formation in the Drosophila Eye Disc	Treisman, Jessica	NSF-IOB	9728140	abstract
hh	Drosophila melanogaster,Triops longicaudatus	Embryo, Limb		Collaborative Research: Developmental Mechanisms Underlying Diversity in Arthropod Limbs	Nagy, Lisa	NSF-IOB	9874624	abstract
hh	Drosophila melanogaster,Triops longicaudatus	Embryo, Limb		Collaborative Research: Developmental Mechanisms Underlying Diversity in Arthropod Limbs	Williams, Terri	NSF-IOB	9904391	abstract
hh, N	Drosophila melanogaster	Embryo		Signal Transduction Pathways in Drosophila Head Development	Finkelstein, Robert	NSF-IOB	9905684	abstract
en	Brachiopods	Embryo		The Developmental Basis for Evolutionary Changes in the Larval Biology of Brachiopods	Freeman, Gary	NSF-IOB	9982025	abstract
hh	Drosophila melanogaster	Embyro,Genital		Regulation of Hedgehog Signaling in the Drosophila Ovary	Montell, Denise	NSF-IOB	9983759	abstract
Gli		Epithelia	cancer	Role of Glil in Basal Cell Carcinoma Development	Ruiz I Altaba, Ariel	NCI	CA078736	abstract
shh		Prostate	cancer	Shh Signaling as a Therapeutic Target in Prostate Cancer	Bushman, Wade A.	NCI	CA095386	abstract
shh,smo,ptc			cancer	Genome-Based Targeting of the Hedgehog Pathway in Cancer	Beachy, Philip A	NCI	CA095957	abstract


Last updated 28-Aug-2006 home page \| about Hedgehog \| gene index © Copyright 2006

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