The Hedgehog Signaling
Pathway Database project description:
The morphogen Hedgehog is an autoproteolytic secreted protein
that activates an essential cellular pathway (Hedgehog Signaling
Pathway) required during the embryogenesis of various organisms.
The pathway is involved in cell fate determination, pattern
formation, proliferation, and differentiation in multiple tissue
types. Its fundamental importance is exemplified by the many
mutations that cause severe developmental defects as well as the
many types of cancers that result from mis-activation.
The Hedgehog Signaling Pathway Website is a resource database
of:
- all genes known to be involved in the Hh
pathway in various organisms. This includes DNA and protein
sequence data, domain structure motifs, molecular interaction
data,
- all known gene targets of the Hh pathway
derived from microarray experiments involving the Hh pathway.
-
all known human diseases associated with the Hh
pathway. This includes experimental data on therapeutic agents and
their molecular targets.
- protocols, tissue cell lines, and reagents used
by Hh pathway researchers.
- annotations contributed by Hh researchers
Currated content found in the Hh database is derived from a variety
sources:
-
comprehensive Genomic databases:
- Ensembl
- NCBI
- pFam
- SMART
- UCSC Genome
- Uniprot
- Genome specific databases
- Flybase
- Wormbase
- MGI
- Xenbase
- Zfin
- Peer reviewed journal publications
- Computational algorithms developed in the
Ramirez-Weber Lab
Funding for this project has been provided by
NIH RIMI 5P20-MD000262
San Francisco State University
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